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1

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

Jeffrey J. Babon, Nadia J. Kershaw, James M. Murphy, Leila N. Varghese, Artem Laktyushin, Samuel N. Young, Isabelle S. Lucet, Raymond S. Norton, Nicos A. Nicola

Journal:

Year:

2012

Language:

english

File:

PDF, 1.73 MB

english, 2012

2

Right Ventricular Failure After Cardiac Surgery: Management Strategies

Shinobu Itagaki, Leila Hosseinian, Robin Varghese

Journal:

Seminars in Thoracic and Cardiovascular Surgery

Year:

2012

Language:

english

File:

PDF, 580 KB

english, 2012

3

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Kershaw, Nadia J, Murphy, James M, Liau, Nicholas P D, Varghese, Leila N, Laktyushin, Artem, Whitlock, Eden L, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J

Journal:

Nature Structural and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.85 MB

english, 2013

4

Inhibition of IL-6 family cytokines by SOCS3

Babon, Jeffrey J., Varghese, Leila N., Nicola, Nicos A.

Journal:

Seminars in Immunology

Year:

2014

Language:

english

File:

PDF, 1.60 MB

english, 2014

5

The molecular regulation of Janus kinase (JAK) activation

Babon, Jeffrey J., Lucet, Isabelle S., Murphy, James M., Nicola, Nicos A., Varghese, Leila N.

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

6

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Murphy, James M., Zhang, Qingwei, Young, Samuel N., Reese, Michael L., Bailey, Fiona P., Eyers, Patrick A., Ungureanu, Daniela, Hammaren, Henrik, Silvennoinen, Olli, Varghese, Leila N., Chen, Kelan, T

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 2.82 MB

english, 2014

7

Results With Syncardia Total Artificial Heart Beyond 1 Year

Torregrossa, Gianluca, Michiel, Morshuis, Varghese, Robin, Hosseinian, Leila, Vida, Vladimiro, Tarzia, Vincenzo, Antonio, Loforte, Duveau, Daniel, Arabia, Francisco, Leprince, Pascal, Kasirajan, Vigne

Journal:

Year:

2014

Language:

english

File:

PDF, 730 KB

english, 2014

8

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

Varghese, Leila N., Ungureanu, Daniela, Liau, Nicholas P. D., Young, Samuel N., Laktyushin, Artem, Hammaren, Henrik, Lucet, Isabelle S., Nicola, Nicos A., Silvennoinen, Olli, Babon, Jeffrey J., Murphy

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

9

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia

Varghese, Leila N., Zhang, Jian-Guo, Young, Samuel N., Willson, Tracy A., Alexander, Warren S., Nicola, Nicos A., Babon, Jeffrey J., Murphy, James M.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.31 MB

english, 2014

10

TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice

Griffin, Cameron, Eter, Leila, Lanzetta, Nico, Abrishami, Simin, Varghese, Mita, McKernan, Kaitlin, Muir, Lindsey, Lane, Jamie, Lumeng, Carey Nien-Kai, Singer, Kanakadurga

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

11

The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin

Varghese, Leila N., Defour, Jean-Philippe, Pecquet, Christian, Constantinescu, Stefan N.

Journal:

Frontiers in Endocrinology

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

12

Sex differences in inflammatory responses to adipose tissue lipolysis in diet-induced obesity

Varghese, Mita, Griffin, Cameron, McKernan, Kaitlin, Eter, Leila, Lanzetta, Nicholas, Agarwal, Devyani, Abrishami, Simin, Singer, Kanakadurga

Journal:

Year:

2018

Language:

english

File:

PDF, 4.62 MB

english, 2018

13

Inflammatory responses to dietary and surgical weight loss in male and female mice

Griffin, Cameron, Hutch, Chelsea R., Abrishami, Simin, Stelmak, Daria, Eter, Leila, Li, Ziru, Chang, Eric, Agarwal, Devyani, Zamarron, Brian, Varghese, Mita, Subbaiah, Perla, MacDougald, Ormond A., Sa

Journal:

Biology of Sex Differences

Year:

2019

Language:

english

File:

PDF, 5.45 MB

english, 2019

14

Inflammatory responses to dietary and surgical weight loss in male and female mice

Griffin, Cameron, Hutch, Chelsea R., Abrishami, Simin, Stelmak, Daria, Eter, Leila, Li, Ziru, Chang, Eric, Agarwal, Devyani, Zamarron, Brian, Varghese, Mita, Subbaiah, Perla, MacDougald, Ormond A., Sa

Journal:

Biology of Sex Differences

Year:

2019

File:

PDF, 5.45 MB

2019

15

The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: recent findings and potential therapeutic applications

Vainchenker, William, Plo, Isabelle, Marty, Caroline, Varghese, Leila N., Constantinescu, Stefan N.

Journal:

Expert Review of Hematology

Year:

2019

Language:

english

File:

PDF, 1.57 MB

english, 2019

16

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

Labuhn, Maurice, Perkins, Kelly, Matzk, Sören, Varghese, Leila, Garnett, Catherine, Papaemmanuil, Elli, Metzner, Marlen, Kennedy, Alison, Amstislavskiy, Vyacheslav, Risch, Thomas, Bhayadia, Raj, Samul

Journal:

Year:

2019

Language:

english

File:

PDF, 4.89 MB

english, 2019

17

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

Labuhn, Maurice, Perkins, Kelly, Matzk, Sören, Varghese, Leila, Garnett, Catherine, Papaemmanuil, Elli, Metzner, Marlen, Kennedy, Alison, Amstislavskiy, Vyacheslav, Risch, Thomas, Bhayadia, Raj, Samul

Journal:

Year:

2019

File:

PDF, 4.89 MB

2019

18

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

Labuhn, Maurice, Perkins, Kelly, Matzk, Sören, Varghese, Leila, Garnett, Catherine, Papaemmanuil, Elli, Metzner, Marlen, Kennedy, Alison, Amstislavskiy, Vyacheslav, Risch, Thomas, Bhayadia, Raj, Samul

Journal:

Year:

2019

Language:

english

File:

PDF, 141 KB

english, 2019

19

MPL membrane domain sequencing goes deep

Constantinescu, Stefan N., Varghese, Leila N.

Journal:

Year:

2020

File:

PDF, 530 KB

2020

20

MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

Levy, Gabriel, Carillo, Serge, Papoular, Benjamin, Cassinat, Bruno, Zini, Jean-Marc, Leroy, Emilie, Varghese, Leila N., Chachoua, Ilyas, Defour, Jean-Philippe, Smith, Steven O., Constantinescu, Stefan

Journal:

Year:

2020

File:

PDF, 1.17 MB

2020